Mark Wahlberg Cade Yeager Josh Duhamel Col. William Lennox Stanley Tucci Merlin Anthony Hopkins Sir Edmund Burton Laura Haddock Vivian Wembley Jerrod Carmichael Jimmy Isabela Merced Izabella Santiago Cabrera Santos John Turturro Seymour Simmons Glenn Morshower General Morshower Liam Garrigan King Arthur Mitch Pileggi TRF Group Leader Tony Hale JPL Engineer Gil Birmingham Chief Sherman Nicola Peltz Beckham Tessa Yeager (voice) Peter Cullen Optimus Prime (voice) Gemma Chan Quintessa Frank Welker Megatron (voice) Erik Aadahl Bumblebee (voice) Sophia Myles Darcy Charlie Bouguenon Namibian Scientist